| AfyPW says : Taking prednisone can make your immune system weaker, so you need to avoid any situation where there may be exposure to infection. You also need to tell your health care provider about any past exposure to a known infection. The immune system can be weakened by certain diseases like HIV/AIDS, or certain infections that may not affect your immunity as much. If any condition of yours is likely to be under a lot of stress for quite some time, which may lead to the need for an adjustment of your dose level
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